Reading nuclear poetry by Pacific Indigenous poets, Craig Santo Perez of Hawaii and Guam Chamorro and Kathy Jetnil-Kijiner of Marshall Islands, this lecture ventures a nuclear criticism in the era of the Anthropocene that recognizes the Indigenous subject in conjunction with the violent history of the nuclear Pacific. The Pacific, the largest ocean on the planet, has been the site of more than 50 years of the most destructive and disastrous nuclear weapons testing, irradiating waters, islands, and islanders. Perez’s and Jetnil-Kijiner’s poetry emerges from their home islands in the Pacific to testify nuclear catastrophe as “a historical, global, and ongoing presence,” to borrow Elizabeth DeLoughrey’s words. I stress the Indigenous significance and examine the ways in which Indigenous Pacific writers bear testimony to radiation ecologies in the Pacific by invoking eco-poetry as a form of resistance against nuclear imperialism/militarism. Such a form also invokes transdisciplinary inquiry into radiation ecologies and would bring together health science with the literary and innovate them in ways that mutually illuminate each other. A vigorous engagement interfacing nuclear criticism and Indigenous resistance poetics would help us better articulate and imagine a healthier and sustainable planet.